2023 2022
2024
Mougin C, Chataigner M, Lucas C, Pallet V, Bouvret E, Joffre C, Dinel AL (2024). Dietary marine hydrolysate alleviates D-galactose-induced brain aging by attenuating cognitive alterations, oxidative stress and inflammation through the AGE RAGE axis. Plos'one, sous presse.
Montaner M, Denom J, Simon V, Jiang W, Holt MK, Brierley DI, Rouch C, Foppen E, Kassis N, Jarriault D, Khan D, Eygret L, Mifsud F, Hodson DJ, Broichhagen J, Van Oudenhove L, Fioramonti X, Gault V, Cota D, Reimann F, Gribble FM, Migrenne-Li S, Trapp S, Gurden H, Magnan C. (2024). A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion. Nat Commun. 2024 Aug 13;15(1):6941. doi: 10.1038/s41467-024-51076-4.
Rhea EM, Leclerc M, Yassine HN, Capuano AW, Tong H, Petyuk VA, Macauley SL, Fioramonti X, Carmichael O, Calon F, Arvanitakis Z. (2024) State of the science on brain insulin resistance and cognitive decline due to Alzheimer's disease. Aging Dis. 2024 Aug 1;15(4):1688-1725. doi: 10.14336/AD.2023.0814.
Yin Z, Herron S, Silveira S, Kleemann K, Gauthier C, Mallah D, Cheng Y, Margeta MA, Pitts KM, Barry JL, Subramanian A, Shorey H, Brandao W, Durao A, Delpech JC, Madore C, Jedrychowski M, Ajay AK, Murugaiyan G, Hersh SW, Ikezu S, Ikezu T, Butovsky O. (2024) Identification of a protective microglial state mediated by miR-155 and interferon-g signaling in a mouse model of Alzheimer's disease. Nat Neurosci. 2023 Jul;26(7):1196-1207. doi: 10.1038/s41593-023-01355-y.
Singhaarachchi PH, Antal P, Calon F, Culmsee C, Delpech JC, Feldotto M, Geertsema J, Hoeksema EE, Korosi A, Layé S, McQualter J, de Rooij SR, Rummel C, Slayo M, Sominsky L, Spencer SJ. (2024). Aging, sex, metabolic and life experience factors: contributions to neuro-inflammaging in Alzheimer's disease research. Neurosci Biobehav Rev. 2024 Jul;162:105724. doi: 10.1016/j.neubiorev.2024.105724.
Metherel AH, Valenzuela R, Klievik BJ, Cisbani G, Rotarescu RD, Gonzalez-Soto M, Cruciani-Guglielmacci C, Layé S, Magnan C, Mutch DM, Bazinet RP. Dietary docosahexaenoic acid (DHA) donwregulated liver DHA synthesis by inhibiting eicosapentaenoic acid elongation. J Lipid Res. 2024 Jun;65(6):100548. doi: 10.1016/j.jlr.2024.100548.
Carneiro L, Fenech C, Liénard F, Grall S, Abed B, Haydar J, Allard C, Desmoulins L, Paccoud R, Brindisi MC, Mouillot T, Brondel L, Fioramonti X, Pénicaud L, Jacquin-Piques A, Leloup C. (2024). Hypothalamic glucose hypersensitivity-induced insulin secretion in obese Zücker rat is reversed by central ghrelin treatment. Antioxid Redox Signal. 2024 May;40(13-15):837-849. doi: 10.1089/ars.2022.0031.
Leon S, Simon V, Lee TH, Steuernagel L, Clark S, Biglari N, Lesté-Lasserre T, Dupuy N, Cannich A, Bellocchio L, Zizzari P, Allard C, Gonzales D, Le Feuvre Y, Lhuillier E, Brochard A, Nicolas JC, Teillon J, Nikolski M, Marsicano G, Fioramonti X, Brüning JC, Cota D, Quarta C. (2024). Single cell tracing of Pomc neurons reveals recruitment of 'ghost' subtypes with atypical identity in a mouse model of obesity. Nat Commun. 2024 Apr 24;15(1):3443. doi: 10.1038/s41467-024-47877-2.
2023
Benson DL, Layé S. Bridging a mechanistic gap from diet to synapses. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2309992120. doi: 10.1073/pnas.2309992120.
Brossaud J, Bosch-Bouju C., Marissal-Arvy N, Walker BR, Webster S, Fioramonti X, Ferreira G, Barat P, Corcuff JB, Moisan MP (2023). Memory deficits in juvenile rats with type 1 diabetes are due to excess 11b-HSD1 activity, up-regulated by high glucose concentration rather than insulin deficiency. Diabetologia, accepted for publication.
Carneiro L, Fenech C, Liénard F, Grall S, Abed B, Haydar J, Allard C, Desmoulins L, Paccoud R, Brindisi MC, Mouillot T, Brondel L, Fioramonti X, Pénicaud L, Jacquin-Piques A, Leloup C. Hypothalamic Glucose Hypersensitivity-Induced Insulin Secretion in the Obese Zücker Rat Is Reversed by Central Ghrelin Treatment.Antioxid Redox Signal. 2023 Mar 7.
Fioramonti X. A New Role for Hypothalamic Glucose-Sensing Neurons in Hypoglycemia Unawareness. Diabetes. 2023 Aug 1;72(8):1055-1056. doi: 10.2337/dbi22-0038.
Guneykaya D, Ugursu B, Logiacco F, Popp O, Feiks MA, Meyer N, Wendt S, Semtner M, Cherif F, Gauthier C, Madore C, Yin Z, Çınar Ö, Arslan T, Gerevich Z, Mertins P, Butovsky O, Kettenmann H, Wolf SA. Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder. Brain Behav Immun. 2023 Jul;111:61-75. doi: 10.1016/j.bbi.2023.03.023. Epub 2023 Mar 29.
Leyrolle Q, Prado-Perez L, Layé S. The gut-derived metabolites as mediators of the effect of healthy nutrition on the brain. Front Nutr. 2023 Jun 9;10:1155533. doi: 10.3389/fnut.2023.1155533. eCollection 2023.
Lopresti AL, Smith SJ, Pouchieu C, Pourtau L, Gaudout D, Pallet V, Drummond PD. Effects of a polyphenol-rich grape and blueberry extract (Memophenol™) on cognitive function in older adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study. Front Psychol. 2023 Mar 29;14:1144231.
Martin H., Bullich S, Martinat M, Chataigner M, Di Miceli M, Simon V, Clark S, Buttler J, M Schell, Simran C, Chaouloff F, Kleinridders A, Cota D, De Deurwaerdere P, Pénicaud L, Layé S, Guiard P. B#, Fioramonti X#, Insulin modulates emotional behavior through a serotonin-dependent mechanism, Molecular Psychiatry, 2023, doi: 10.1038/s41380-022-01812-3.
Mougin C., Chataigner M., Lucas C., Leyrolle Q., Pallet V., Layé S., Bouvret E., Dinel A.L., Joffre C. Dietary Marine Hydrolysate Improves Memory Performance and Social Behavior through Gut Microbiota Remodeling during Aging. Foods, 2023, 12, 4199. doi.org/10.3390/foods12234199
Picard K, Corsi G, Decoeur F, Di Castro MA, Bordeleau M, Persillet M, Layé S, Limatola C, Tremblay ME*, Nadjar A* Microglial population turnover modulates non-rapid eye movement sleep duration in adult female mice, Brain Behavior and Immunity, 2023, 107:153-164.
Rhea EM, Leclerc M, Yassine HN, Capuano AW, Tong H, Petyuk VA, Macauley SL, Fioramonti X, Carmichael O, Calon F, Arvanitakis Z. State of the Science on brain insulin resistance and cognitive decline due to Alzheimer's disease. Aging Dis. 2023 Aug 17. doi: 10.14336/AD.2023.0814.
de Rus Jacquet A, Layé S, Calon F. How nutrients and natural products act on the brain: Beyond pharmacology. Cell Rep Med. 2023 Oct 17;4(10):101243. doi: 10.1016/j.xcrm.2023.101243.
Soubeyre V, Merle L, Jarriault D, Grégoire S, Bretillon L, Acar N, Grosmaitre X, Le Bon AM. Dietary n-3 polyunsaturated fatty acid deficiency alters olfactory mucosa sensitivity in young mice but has no impact on olfactory behavior. Nutr Neurosci. 2023 Aug;26(8):706-719.
Turpin V, Schaffhauser M, Thabault M, Aubert A, Joffre C, Balado E, Longueville JE, Francheteau M, Burucoa C, Pichon M, Layé S, Jaber M. Mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets. Sci Rep. 2023 Jul 11;13(1):11235. doi: 10.1038/s41598-023-38423-z.
Yin Z, Herron S, Silveira S, Kleemann K, Gauthier C, Mallah D, Cheng Y, Margeta MA, Pitts KM, Barry JL, Subramanian A, Shorey H, Brandao W, Durao A, Delpech JC, Madore C, Jedrychowski M, Ajay AK, Murugaiyan G, Hersh SW, Ikezu S, Ikezu T, Butovsky O. Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer's disease. Nat Neurosci. 2023 Jul;26(7):1196-1207.
2022
Aby F, Lorenzo LE, Grivet Z, Bouali-Benazzouz R, Martin H, Valerio S, Whitestone S, Isabel D, Idi W, Bouchatta O, De Deurwaerdere P, Godin AG, Herry C, Fioramonti X, Landry M, De Koninck Y, Fossat P. Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain. Sci Adv. 2022 8(30):eabo0689.
Ahmed H, Leyrolle Q, Koistinen V, Kärkkäinen O, Layé S, Delzenne N and Hanhineva K, Microbiota-derived nutritional metabolites as drivers of gut-brain communication, Gut Microbe, 2022, 4(1):2102878
Costa A, Rani B, Bastiaanssen TFS, Bonfiglio F, Gunnigle E, Provensi G, Rossitto M, Boehme M, Strain C, Martínez CS, Blandina P, Cryan JF, Layé S, Corradetti R, Passani MB (2022). Diet prevents social stress-induced maladaptive neurobehavioral and gut microbiota changes in a histamine-dependent manner. Int J Mol Sci 23(2):862. doi: 10.3390/ijms23020862.
Cox LM, Calcagno N, Gauthier C, Madore C, Butovsky O, Weiner HL (2022). The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis. Microbiome 10(1):47. doi: 10.1186/s40168-022-01232-z.
Dalile B, Kim C, Challinor A, Geurts L, Gibney ER, Galdos MV, La Fata G, Layé S, Mathers JC, Vauzour D, Verkuyl MJ and Thuret S, Sustainable diet, sustainable brain? The EAT-Lancet reference diet and cognitive function across the life course, The Lancet Planetary Health, 2022, 6(9):e749-e759
Decoeur F, Picard K, St-Pierre MK, Greenhalgh AD, Delpech JC, Sere A, Layé S, Tremblay ME, Nadjar A (2022). n-3 PUFA Deficiency affects ultrastructure organization and density of white matter microglia in the developing brain of male mice. Front Cell Neurosci. 16:802411. doi: 10.3389/fncel.2022.802411.
Di Miceli M, Martinat M, Rossitto M, Aubert A, Alashmali S, Bosch-Bouju C, Fioramonti X, Joffre C, Bazinet RP, Layé S. (2022). Dietary long-chain n-3 polyunsaturated fatty acid supplementation alters electrophysiological properties in the nucleus accumbent and emotional behavior in naïve and chronically stressed mice. Int J Mol Sci 23(12):6650. doi: 10.3390/ijms23126650.
Fulton S, Décarie-Spain L, Fioramonti X, Guard B, Nakajima S (2022). The menace of obsity to depression and anxiety prevalence. Trends Endocrinol Metabolism 33(1):18-35. doi: 10.1016/j.tem.2021.10.005.
Herron S, Delpech JC, Madore C, Ikezu T. Using mechanical homogenization to isolate microglia from mouse brain tissue to preserve transcriptomic integrity.
STAR Protoc. 2022, 3(4):101670.
Karadayi R, Mazzocco J, Leclere L, Buteau B, Gregoire S, Belloir C, Koudsi M, Bessard P, Bizeau JB, Dubus E, Fenech C, Briand L, Bretillon L, Bron AM, Fioramonti X, Acar N. Plasmalogens Regulate Retinal Connexin 43 Expression and Müller Glial Cells Gap Junction Intercellular Communication and Migration. Front Cell Dev Biol. 2022, 10:864599.
Le Faouder J, Arnaud B, Lavigne R, Lucas C, Com E, Bouvret E, Dinel A.L., Pineau C (2022). Fish hydrolysate supplementation prevents stress-induced dysregulation of hippocampal and proteins relative to mitochondrial metabolism and the neuronal network in mice. Foods 11, 1591.
Leyrolle Q, Decoeur F, Dejean C, Brière G, Leon S, Bakoyiannis I, Baroux E, Sterley TL, Bosch-Bouju C, Morel L, Amadieu C, Lecours C, St-Pierre MK, Bordeleau M, De Smedt-Peyrusse V, Séré A, Schwendimann L, Grégoire S, Bretillon L, Acar N, Joffre C, Ferreira G, Uricaru R, Thebault P, Gressens P, Tremblay ME, Layé S, Nadjar A (2022). n-3 deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development. Glia Sep 14. doi: 10.1002/glia.24088.
Margeta MA, Yin Z, Madore C, Pitts KM, Letcher SM, Tang J, Jiang S, Gauthier CD, Silveira SR, Schroeder CM, Lad EM, Proia AD, Tanzi RE, Holtzman DM, Krasemann S, Chen DF, Butovsky O. Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma.Immunity. 2022, 55(9):1627-1644.e7.
Muller T, Demizieux L, Troy-Fioramonti S, Buch C, Leemput J, Belloir C, Pais de Barros JP, Jourdan T, Passilly-Degrace P, Fioramonti X, Le Bon AM, Vergès B, Robert JM, Degrace P. (2022). Chemical synthesis, Pharmacokinetic properties and biological effects of JM-00266, a putative non-brain penetrant cannabinoid receptor 1 inverse agonist. Int J Mol Sci. 23(6):2923. doi: 10.3390/ijms23062923
Soubeyre V, Merle L, Jarriault D, Grégoire S, Bretillon L, Acar N, Grosmaitre X, Le Bon AM. Dietary n-3 polyunsaturated fatty acid deficiency alters olfactory mucosa sensitivity in young mice but has no impact on olfactory behavior. Nutr Neurosci. 2022, 1-14.
Tremblay ME, Madore C, Tian L, Verkhratsky A (2022). Editorial: Role of neuroinflammation in the neuropsychiatric and neurological aspects of COVID-19. Front Cell Neurosci. 16:840121. doi: 10.3389/fncel.2022.840121.
Yu D, Li T, Delpech JC, Zhu B, Kishore P, Koshi T, Luo R, Pratt KJB, Popova G, Nowakowski TJ, Villeda SA, Piao X. (2022). Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits. Sci Adv. 8(18):eabm2545. doi: 10.1126/sciadv.abm2545.
